Abstract

Editorial

Neutrophil to Lymphocyte Ratio (NLR) in Peripheral Blood: A Novel and Simple Prognostic Predictor of Non-small Cell Lung Cancer (NSCLC)

Xiaoli Zhang, Ziyuan Zou, Liyu Fan, Xinjie Xu, Yu Siyuan and Peng Luo*

Published: 30 March, 2017 | Volume 1 - Issue 1 | Pages: 011-013

Lung cancer is the leading cause of cancer-related deaths worldwide, and almost accounts for 20% of these deaths, however, the cure rate is less than 10% [1]. Non-small cell lung cancer (NSCLC) accounts for approximately 85% of all cases of lung cancer [1], but fewer than 15% of individuals diagnosed with NSCLC can survive for more than 5 years, which poses a great threat to the patient’s life and health [2]. Recently, the incidence of lung cancer keeps dynamically growing, but more than 75% of patients at diagnosis has appeared local development or metastasis, missing the best period of surgery. Moreover, despite surgical treatment is the optimal choice for early-stage NSCLC patients, 30%-40% of patients with NSCLC develop tumor recurrence in a short time. Therefore, improving the prognosis of patients with lung cancer and predicting the long-term survival of patients is of particular importance [3]. At present, tumor and node metastasis (TNM) staging system, clinicopathological characteristics, visceral pleural invasion and marginal status are used to predict the disease progression and overall survival of NSCLC patients. There is no index which is stable, effective, reliable and less harmful to assess prognosis, predict recurrence risk and overall survival.

Read Full Article HTML DOI: 10.29328/journal.jhcr.1001002 Cite this Article Read Full Article PDF

Keywords:

Neutrophil to Lymphocyte Ratio; NLR; Prognostic Predictor; Systematic Inflammation; Non-small Cell Lung Cancer; NSCLC

References

  1. Dirican N, Dirican A, Anar C, Atalay S, Ozturk O, et al. A New Inflammatory Prognostic Index, Based on C-reactive protein, the Neutrophil to Lymphocyte Ratio and Serum Albumin is Useful for Predicting Prognosis in Non-Small Cell Lung Cancer Cases. Asian Pac J Cancer Prev. 2016; 17: 5101-5106. Ref.: https://goo.gl/k3vLfQ
  2. Wang J, Kalhor N, Hu J, Wang B, Chu H, et al. Pretreatment Neutrophil to Lymphocyte Ratio Is Associated with Poor Survival in Patients with Stage I-III Non-Small Cell Lung Cancer. PloS one. 2016; 11. Ref.: https://goo.gl/GjnBc1
  3. Jin F, Han A, Shi F, Kong L, Yu J, et al. The postoperative neutrophil-to-lymphocyte ratio and changes in this ratio predict survival after the complete resection of stage I non-small cell lung cancer. OncoTargets ther. 2016; 9: 6529-6537. Ref.: https://goo.gl/tAJlnN
  4. Tomita M, Shimizu T, Ayabe T, Nakamura K, Onitsuka T, et al. Elevated preoperative inflammatory markers based on neutrophil-to-lymphocyte ratio and C-reactive protein predict poor survival in resected non-small cell lung cancer. Anticancer res. 2012; 32: 3535-3538. Ref.: https://goo.gl/ZM93k9
  5. Gu XB, Tian T, Tian XJ, Zhang XJ. Prognostic significance of neutrophil-to-lymphocyte ratio in non-small cell lung cancer: a meta-analysis. Sci Rep. 2015; 5: 12493. Ref.: https://goo.gl/jOfxEL
  6. Peng B, Wang Y H, Liu Y M, Ma LX. Prognostic significance of the neutrophil to lymphocyte ratio in patients with non-small cell lung cancer: a systemic review and meta-analysis. Int J Clin Exp Med. 2015; 8: 3098-3106. Ref.: https://goo.gl/XJ7Prw
  7. Eryilmaz M K, Mutlu H, Salim D K, Musri FY, Tural D, et al. The neutrophil to lymphocyte ratio has a high negative predictive value for pathologic complete response in locally advanced breast cancer patients receiving neoadjuvant chemotherapy. Asian Pac J Cancer Prev. 2014; 15: 7737-7740. Ref.: https://goo.gl/vgeXCu

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